The first owners of the mansion were the Düzoğulları family. The mansion, inherited from the Düzoğulları, was completely demolished by the Aristarhis family and rebuilt in 1863.

In 1876, the mansion came into the possession of Prince Abdülhalim Pasha, the son of Kavalalı Mehmet Ali Pasha, the Governor of Egypt. It was reconstructed in its current form by the architect Petraki Adamandidis from Çanakkale.

After the death of Abdülhalim Pasha, the mansion was inherited by his nine children. Sait Halim Pasha acquired his siblings' shares, becoming the sole owner of the mansion.

Pasha frequently gathered music masters at the mansion, where servants served ice cream and sherbet on silver trays to hundreds of boats that docked at the mansion's pier. Thus, the mansion began to be regarded as an academy of Turkish music.

With Sait Halim Pasha's first official appointment, two lion statues were gifted from Germany and Italy, which led to the mansion being referred to as the "Mansion of Lions."

The alliance agreement between Germany's ambassador Wangenheim and the Ottoman Empire was signed in Sait Halim Pasha's Study.

After the death of Sait Halim Pasha, the ownership of the mansion passed to his son, Prince Halim Said.

The mansion became a favorite symbol of wealth in Yeşilçam (Turkish film industry) and has been featured in numerous films.

The heirs sold the mansion to Tourism Bank, and it was used for touristic purposes until 1980.

A casino was opened within the mansion, accessible only to foreigners.

While the mansion continued to host unforgettable films of Turkish cinema, it also appeared in the Hollywood production "You Can’t Win ‘Em All," starring Charles Bronson and Tony Curtis.

It hosted some of the most unforgettable films in Turkish cinema.

The mansion was restored by Tourism Bank through the TAÇ (Turkey Monument and Environmental Protection) Foundation.

Tourism Bank was converted into the Development Bank of Turkey; during this period, the mansion's garden was operated as a restaurant in the summer months, and some of its rooms were arranged as a museum.

While it served as the official guesthouse of the Prime Ministry, the mansion suffered a fire and was restored under the leadership of Prof. Dr. Doğan Kuban to reflect its original form from the 1860’s.

Since having been transferred to the private sector in 2005, Sait Halim Pasha Mansion has become one of Istanbul’s most preferred event venues, hosting numerous weddings and social and corporate events throughout the year.